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老年恶性胶质瘤患者的护理模式和结果:来自3个伦巴蒂大区医院的151名患者的数据

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发布于 2017-4-28 08:51:43 | 显示全部楼层 |阅读模式
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外文标题: Pattern of care and outcome in elderly patients with glioblastoma: Data in 151 patients from 3 Lombardia Hospitals
外文摘要: The appropriate treatment approach for elderly patients with glioblastoma multiforme (GBM) is unclear, al-though different studies suggest survival benefitinfit patients treated with radiotherapy and chemiotherapy after surgery. We performed a retrospective analysis of 151 patients older than 65 years with GBM treated in 3 Lombardia Hospitals. In univariate regression analysis higher KPS (p = 0.02), macroscopical total resection (p b 0.003), radiotherapy (p b 0.0001), chemotherapy (p b 0.0001) and second line chemotheraphy (p = 0.02) were of positive prognostic value. On the contrary older age (N70 years), presence of seizure at onset and addi-tional resection after tumor recurrence did not influence OS. Multivariate analysis revealed radiotherapy (HR 0.2 p b 0.0001) and extent of surgery (HR 0.3, p = 0,0063) as positive independent prognostic factors. Patients re-ceiving radio-chemiotherapy displayed more treatment-related toxicities with a slightly prolonged OS versus those receiving hypofractionated radiotherapy. With the limits of a retrospective study, our data suggest that in elderly fit patients extensive surgery should be considered, moreover adjuvant treatments led to an increase in OS. Randomized controlled study are needed to develop treatment guidelines for elderly GBM patients and to assess whether the combination of post-surgical radio and chemiotherapy may be superior to hypofractionated radiotherapy and chemiotherapy in fit patients.
英关键词: Glioblastoma Elderly Survival Radiotherapy, Chemotherapy Extent of resection
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译文标题: 老年恶性胶质瘤患者的护理模式和结果:来自3个伦巴蒂大区医院的151名患者的数据
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Pattern of care and outcome in elderly patients with glioblastoma_ Data in 151 p.pdf

 
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Pattern of care and outcome in elderly patients with glioblastoma_ Data in 151 p.pdf

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